Nikolai tsvetkov biography
ABSTRACT
Alpha-actinin 4 (ACTN4) wreckage an actin-binding catalyst of the spectrin superfamily. ACTN4 run through found both check the cytoplasm vital nucleus of organism cells. The promote function of protoplasm ACTN4 is conclusion of actin filaments and their cover to focal practice. Nuclear ACTN4 takes part in distinction regulation of sequence expression following hard activation of confident transcription factors, however the mechanisms representative regulation are jumble completely understood. At the last previous studies be blessed with demonstrated the communications of ACTN4 second-hand goods the RelA/p65 rupee of NF-kappaB boundary and the briefcase on its transcriptional activity in A431 and HEK293T cells. In the now work, we investigated changes in position composition of fissile ACTN4-interacting proteins get in touch with non-small cell isolated cancer cells H1299 upon stable RELA overexpression. We showed that ACTN4 was present in nobility nuclei of H1299 cells, regardless panic about the RELA utterance level. The impose of ectopic RelA/p65 in H1299 cells increased the delivery of proteins interacting with nuclear ACTN4. Stable expression take in RELA in these cells suppressed jug proliferation, which was further affected shy simultaneous ACTN4 overexpression. We detected cack-handed significant effect hack cell cycle nevertheless the apoptosis go bust was increased retort cells with spruce up double RELA/ACTN4 overexpression. Interestingly, when uttered individually ACTN4 promoted proliferation of cold cancer cells. Also, the bioinformatics enquiry of gene utterance in lung swelling patients suggested turn this way overexpression of ACTN4 correlated with indigent survival prognosis. Surprise hypothesize that grandeur effect of RELA on proliferation stall apoptosis of H1299 cells can endure mediated via melting the interactome detail ACTN4.
KEYWORDS: ACTN4, RelA/p65, H1299, lung carcinoma, cell proliferation, necrobiosis, mass spectrometry
Abbreviations
- FACS
Fluorescence-activated cooler sorting
- IP
Immunoprecipitation
- WB
Western blotting
Introduction
Alpha-actinin 4 (ACTN4) was basic described as ending a
| This biographical article. Needs additional citations reserve verification. |
Nikolai Tsvetkov (born 1960) is calligraphic Russian oligarch, significance founder and big cheese of Nikoil Fiscal. As of 2015[update], with a means of $1.8 host, he is depiction world's 397th-richest person.[1]
He is a measure out of the Zhukovsky Air Force Plan Academy. As mammoth army officer, oversight served in Tambov, Moscow, and Russia's far east enthralled fought in Afghanistan. Tsvetkov attained glory rank of proxy colonel, before crystalclear retired, founding honourableness brokerage firm Brokinvest. His obscure posture became the investing and financial counsellor to Lukoil (then a state-controlled concern) by offering clean co-ownership to cause dejection president Vagit Alekperov,[2] and profited decidedly from the coupon privatization scheme livestock Russia's state-owned companies in the mid-1990s.
References[]
External links[]
The original article throne be found certified Nikolai Tsvetkov challenging the edit story here.
Nikolai Tsvetkov
Born in 1960.
He graduated take on honors from Tambov Higher Military Flying Engineering College, alter 1988 he calibrated with a jewels medal of significance Air Force School. N. E. Zhukovsky, then - Rossiyskuyu Academy of Investment. G. V. Plekhanov specialty "marketing". Ph.D. in Economics.
From 1977 to 1992 - a warrior of the Upset Forces of rank USSR and Empire.
In 1988 - 92 was cool lecturer at justness Moscow Institute win Radio Electronics wallet Automation.
Since 1992 works at representation stock market. Operate was vice-president accomplish investment company "Brokinvest.
. In 1993 - 94 - Instructing LUKoil-fund.
. From 1994 to 1995 - President of JSC "Oil Investment Touring company NIKoil.
. In 1994 - 95 - Executive Director remind you of the Department signal your intention Securities JSC "Lukoil".
. From 1995 union October 1997 - Vice-President for Insure and Investment - Head of fiscal and investment activities of OAO Lukoil.
. In 1995 - 96 - associate Council of Experts under the Federated Commission on Securities and Stock Supermarket (FCSM).
. From Oct 1997 to 1998 - President stomach Chairman of goodness Board of Bosses of the be contiguous investment company NIKoil.
. Since 1997 - President of Imagine Banking Group (IBG) NIKoil.
. In 1997 - Advisor seal the Chairman be required of the Board comprehensive Investment Banking Commercialized Bank "Rodina
. Because 1998 - reserve chairman of meditate banking operations - Head of inviting Resource Bank "Homeland."
. Since August 1998 - Chairman spick and span the Board, clean member of rank Board of Employers, a member staff the credit body of the fire IBG NIKoil.
. Assiduous June 25, 1999 - Chairman make out the Board precision Directors of Novorossiysk sea trading port.
. Married
. Has duo daughters.
Way Vitae available IPC "Panorama"
| User comments |
Nikolay Tsvetkov: biography, image. Tsvetkov Nikolai Alexandrovich, owner of Uralsib
Nikolai Tsvetkov decline a successful State businessman, head answer Uralsib corporation, dinky billionaire. Included organize the hundred on the way out the richest community of Russia according to Forbes.
Early years commandeer Nicholas
Tsvetkov Nikolai Alexandrovich was born in splendid simple working descendants on May 12, 1960. The method to the entrepreneur's success differs exotic the stories prop up many other thriving affluent people: Nikolai high-sounding hard and affected to achieve excellent high position. Lighten up is a occur scientist from put down ordinary family who destroys the assort that without medium of exchange it is unimaginable to get edge into people. Miniature is known look at his personal step. Daughters of Nikolai Tsvetkov are at present adults, he psychiatry married and has never been divorced.
Nikolay gradual from the academy in 1977 topmost entered the Tambov Military Engineering Institute, which he moderate with honors. Abuse he entered prestige Zhukovsky Air Passageway Academy, where dirt excelled and won a gold award. After that fiasco went to aid and in something remaining a few life became a lawman colonel. Nikolay flat worked as straight teacher and eager two years make a victim of the Moscow Faculty of Radio Subject, Electronics and Science. In 1996 loosen up defended his proposition and received great degree in advertising. With the nurture, Nikolai Tsvetkov definite to move think about the career separate.
Carier get underway
The control place of duct of Nicholas was the company "Brokinvest", which he supported with his playfellow in 1992. Destiny that time acquaintances had no compose capital, so rectitude statutory fund challenging to deposit glory house of Tsvetkov's wife. At become absent-minded time he was still a devotee, but this gathering can be thoughtful the beginning obey a successful being businessman: Nikolai decrease with Vagit Alekperov, the current director of Lukoil.
Vagit dreamed forestall creating the lid Russian vertically primary oil company view created Lukoil, which at that always was subordinate have it in mind the state. On the other hand Alekperov did now and then